Conformational and Quantitative Structure−Activity Relationship Study of Cytotoxic 2-Arylidenebenzocycloalkanones-Reference-Cited by-同舟云学术

Conformational and Quantitative Structure−Activity Relationship Study of Cytotoxic 2-Arylidenebenzocycloalkanones

Published:1999-04-02 Issue:8 Volume:42 Page:1358-1366
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dimmock Jonathan R.¹,Kandepu N. Murthi¹,Nazarali Adil J.¹,Kowalchuk Travis P.¹,Motaganahalli Narasimhan¹,Quail J. Wilson¹,Mykytiuk Patricia A.¹,Audette Gerald F.¹,Prasad Lata¹,Perjési Pál¹,Allen Theresa M.¹,Santos Cheryl L.¹,Szydlowski Jen¹,De Clercq Erik¹,Balzarini Jan¹

Affiliation:

1. College of Pharmacy and Nutrition and Departments of Chemistry and Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada, Department of Medical Chemistry, University Medical School of Pécs, H-7624 Pécs, Hungary, Department of Pharmacology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9806695

Reference32 articles.

1. 1-p-Chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one hydrobromide, a sulfhydryl-specific compound which reacts irreversibly with protein thiols but reversibly with small molecular weight thiols

2. Degradation and Inactivation of Antitumor Drugs

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