Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S2′ Pocket-Reference-Cited by-同舟云学术

Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S2′ Pocket

Published:2009-07-17 Issue:23 Volume:52 Page:7604-7617
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hidaka Koushi¹,Kimura Tooru¹,Abdel-Rahman Hamdy M.¹,Nguyen Jeffrey-Tri¹,McDaniel Keith F.²,Kohlbrenner William E.²,Molla Akhteruzzaman²,Adachi Motoyasu³,Tamada Taro³,Kuroki Ryota³,Katsuki Noriko¹,Tanaka Yoshiaki¹,Matsumoto Hikaru¹,Wang Jun¹,Hayashi Yoshio¹,Kempf Dale J.²,Kiso Yoshiaki¹

Affiliation:

1. Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan

2. Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064

3. Molecular Structural Biology Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki, 319-1195, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9005115

Reference43 articles.

1. Non-Peptidic HIV Protease Inhibitors

2. Peptidomimetic Inhibitors of HIV Protease

3. Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.

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