Mechanism of Proton Transfer in the Isomerization of 5-Androstene-3,17-dione by 3-Oxo-Δ5-steroid Isomerase and Its D38E Mutant-Reference-Cited by-同舟云学术

Mechanism of Proton Transfer in the Isomerization of 5-Androstene-3,17-dione by 3-Oxo-Δ5-steroid Isomerase and Its D38E Mutant

Published:1996-01-01 Issue:20 Volume:35 Page:6438-6442
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Zawrotny Michael E.¹,Hawkinson David C.¹,Blotny Grzegorz¹,Pollack Ralph M.¹

Affiliation:

1. Laboratory for Chemical Dynamics, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 5401 Wilkens Avenue, Baltimore, Maryland 21228-5398, and Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi953025x

Reference35 articles.

1. Recent Studies on Steroid Isomerases From Pseudomonas Testosteroni and Pseudomonas Putida

2. Mechanism of Action of Aldolase and Phosphotriose Isomerase

3. Affinity alkylation of 3-oxo-.DELTA.5-steroid isomerase by steroidal 3.beta.-oxiranes: identification of the modified amino acid by reduction with hydroxyborohydride

4. Mechanism of the Reaction Catalyzed by .DELTA.5-3-Ketosteroid Isomerase of Comamonas (Pseudomonas) testosteroni: Kinetic Properties of a Modified Enzyme in Which Tyrosine 14 Is Replaced by 3-Fluorotyrosine

5. Active Site Phenylalanine of 3-Oxo-.DELTA.5-Steroid Isomerase is Catalytically Important for Proton Transfer

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Theoretical study of enzymatically catalyzed tautomerization of carbon acids in aqueous solution: quantum calculations and steered molecular dynamics simulations;Journal of Molecular Modeling;2016-01-27

2. Experimental Evidence for Enzyme-Enhanced Coupled Motion/Quantum Mechanical Hydrogen Tunneling by Ketosteroid Isomerase;Journal of the American Chemical Society;2008-04-22

3. Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase;Bioorganic Chemistry;2004-10

4. Molecular Dynamics and Quantum Chemical Studies on the Catalytic Mechanism of Δ5-3-Ketosteroid Isomerase: The Catalytic Diad versus the Cooperative Hydrogen Bond Mechanism;Journal of the American Chemical Society;2003-01-01

5. Isomerizations;Organic Chemistry of Enzyme-Catalyzed Reactions;2002