Molecular Dynamics and Quantum Chemical Studies on the Catalytic Mechanism of Δ5-3-Ketosteroid Isomerase: The Catalytic Diad versus the Cooperative Hydrogen Bond Mechanism
Author:
Affiliation:
1. Contribution from the 152 Davey Laboratory, Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802-6300
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja0208097
Reference61 articles.
1. A Proficient Enzyme
2. Solution Structure of 3-Oxo-Δ 5 -Steroid Isomerase
3. High-Resolution Crystal Structures of Δ5-3-Ketosteroid Isomerase with and without a Reaction Intermediate Analogue
4. Detection of Large pK Perturbations of an Inhibitor and a Catalytic Group at an Enzyme Active Site, a Mechanistic Basis for Catalytic Power of Many Enzymes
5. Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters
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