S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase-Reference-Cited by-同舟云学术

S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

Published:2011-11-28 Issue:1 Volume:3 Page:15-19
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bergman Joel A.¹,Hahne Kalub¹,Song Jiao¹,Hrycyna Christine A.¹,Gibbs Richard A.¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology and the Center for Cancer Research, and ‡Department of Chemistry and the Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml200106d

Reference32 articles.

1. PostprenylationCAAXProcessing Is Required for Proper Localization of Ras but Not Rho GTPases

2. Thematic review series: Lipid Posttranslational Modifications. Farnesyl transferase inhibitors

3. Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

4. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

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