Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity

Author:

Ballari María SolORCID,O. J. Porta ExequielORCID,Zalazar Evelyn Arel,Etichetti Carla M. Borini,Padrón José M.ORCID,Girardini Javier E.ORCID,Labadie Guillermo R.ORCID

Funder

Fondo para la Investigación Científica y Tecnológica

Agencia Canaria de Investigación, Innovación y Sociedad de la Información

Universidad Nacional de Rosario

University of the East

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Santafesina de Ciencia, Tecnología e Innovación

Federación Española de Enfermedades Raras

ANPCyT

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference52 articles.

1. International Agency for Research on Cancer - WHO. Global Cancer Observatory. https://gco.iarc.fr/. https://gco.iarc.fr/.

2. Beyond the mevalonate pathway: control of post-prenylation processing by mutant p53;Borini Etichetti;Front Oncol,2020

3. Targeting protein prenylation for cancer therapy;Berndt;Nat Rev Cancer,2011

4. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents;Yang;Amino Acids,2017

5. Small change, big effect: taking RAS by the tail through suppression of post-prenylation carboxylmethylation;Lau;Small GTPases.,2018

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