1. Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan, School of Pharmaceutical Sciences and COE Program in the 21st Century, University of Shizuoka, 52-1 Yada Suruga-ku, Shizuoka, 422-8526, Japan, PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan. and School of Pharmaceutical Sciences, Kitasato University, Shirokane, 5-9-1, Minato-ku, Tokyo, 108-8641, Japan