Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A-Reference-Cited by-同舟云学术

Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A

Published:2015-09-23 Issue:19 Volume:80 Page:9610-9619
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Bowman Roy K.¹,Bullock Kae M.¹,Copley Royston C. B.²,Deschamps Nicole M.¹,McClure Michael S.¹,Powers Jeremiah D.¹,Wolters Andy M.³,Wu Lianming³,Xie Shiping³

Affiliation:

1. Product Development, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, Durham, North Carolina 27709, United States

2. Molecular Discovery Research, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom

3. Product Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5b01598

Reference26 articles.

1. World Health Organization (WHO). Hepatitis C Fact SheetNo. 164, updated April 2014: http://www.who.int/mediacentre/factsheets/fs164/en/index.html(accessed July 7, 2015) .

2. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

3. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

4. In VitroCharacterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

5. Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase

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