Unexpected Retroaldol-Aldol Reaction during O-Alkylation of Hydroxylated Vince Lactam Derivatives
Author:
Affiliation:
1. Department of Medicinal Chemistry, CVMD iMed, AstraZeneca R&D Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5b02404
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3. Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
4. 2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics
5. Rearrangements and unusual reductions with sodium hydride and methyl iodide
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