Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins

Author:

Bonepally Karunakar Reddy1,Takahashi Norihito1,Matsuoka Naoya1,Koi Hikari1,Mizoguchi Haruki2ORCID,Hiruma Takahisa2,Ochiai Kyohei2,Suzuki Shun2,Yamagishi Yutaka2,Oikawa Hideaki2ORCID,Ishiyama Aki3,Hokari Rei3,Iwatsuki Masato3,Otoguro Kazuhiko3,O̅mura Satoshi3,Kato Nobutaka4,Oguri Hiroki5ORCID

Affiliation:

1. Division of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan

2. Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan

3. Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

4. Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, United States

5. Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Funder

Naito Foundation

Ministry of Education, Culture, Sports, Science and Technology

Uehara Memorial Foundation

Global Health Innovative Technology Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

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