Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production-Reference-Cited by-同舟云学术

Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production

Published:2016-05-20 Issue:11 Volume:81 Page:4736-4743
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Achmatowicz Michal M.¹,Allen John G.²,Bio Matthew M.¹,Bartberger Michael D.²,Borths Christopher J.¹,Colyer John T.¹,Crockett Richard D.¹,Hwang Tsang-Lin¹,Koek Jan. N.³,Osgood Stephen A.⁴,Roberts Scott W.¹,Swietlow Aleksander⁴,Thiel Oliver R.¹,Caille Seb¹

Affiliation:

1. Pivotal Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Discovery Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Syncom BV, Kadijk 3, Groningen 9747 AT, The Netherlands

4. Attribute Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.6b00646

Reference23 articles.

1. Development and Production of Commercial Therapeutic Monoclonal Antibodies in Mammalian Cell Expression Systems: An Overview of the Current Upstream Technologies

2. Fucose: biosynthesis and biological function in mammals

3. Optimal and consistent protein glycosylation in mammalian cell culture

4. Allen, J. G.; Mujacic, M.; Frohn, M. J.; Pickrell, A. J.; Kodama, P.; Bagal, D.; San Miguel, T.; Sickmier, E. A.; Osgood, S.; Swietlow, A.; Li, V.; Jordan, J. B.; Kim, K.W.; Russo, A.M.; Kim, Y.J.; Caille, S.; Achmatowicz, M.; Thiel, O.; Fotsch, C. H.; Reddy, P.; McCarter, J. D.Submitted for publication.

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