Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates-Reference-Cited by-同舟云学术

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

Published:2020 Issue:47 Volume:56 Page:6408-6411
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Valverde Pablo¹²³⁴⁵^ORCID,Vendeville Jean-Baptiste¹²³⁴,Hollingsworth Kristian⁶⁷⁸⁴^ORCID,Mattey Ashley P.⁹¹¹⁰¹¹⁴^ORCID,Keenan Tessa¹²¹³¹⁴⁴^ORCID,Chidwick Harriet¹²¹³¹⁴⁴,Ledru Helene¹¹⁵¹⁶¹⁷⁴,Huonnic Kler¹²³⁴,Huang Kun⁹¹¹⁰¹¹⁴^ORCID,Light Mark E.¹²³⁴^ORCID,Turner Nicholas⁹¹¹⁰¹¹⁴^ORCID,Jiménez-Barbero Jesús⁶⁷⁸⁴¹⁸^ORCID,Galan M. Carmen¹¹⁵¹⁶¹⁷⁴^ORCID,Fascione Martin A.¹²¹³¹⁴⁴^ORCID,Flitsch Sabine⁹¹¹⁰¹¹⁴^ORCID,Turnbull W. Bruce⁶⁷⁸⁴^ORCID,Linclau Bruno¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Southampton

3. Southampton SO17 1BJ

4. UK

5. CIC bioGUNE

6. School of Chemistry and Astbury Centre for Structural Molecular Biology

7. University of Leeds

8. Leeds

9. Manchester Institute of Biotechnology (MIB)

10. University of Manchester

11. Manchester

12. Department of Chemistry

13. University of York

14. Heslington

15. Cantock's Close

16. University of Bristol

17. Bristol

18. Ikerbasque

Abstract

A chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose, using a d- to l-sugar translation strategy, and its enzymatic activation and glycosylation, is reported.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

H2020 European Research Council

Agencia Estatal de Investigación

Ministerio de Educación, Cultura y Deporte

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02209H

Reference36 articles.

1. Biological functions of fucose in mammals

2. Fucose: biosynthesis and biological function in mammals

3. Exploring the Structural Diversity of Mammalian Carbohydrates (“Glycospace”) by Statistical Databank Analysis

4. Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases

5. Glycosylation Changes in Brain Cancer

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