Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine-Reference-Cited by-同舟云学术

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Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine

Published:2019-05-24 Issue:12 Volume:84 Page:8006-8018
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Molinaro Carmela¹,Phillips Eric M.¹^ORCID,Xiang Bangping¹,Milczek Erika¹^ORCID,Shevlin Michael¹^ORCID,Balsells Jaume²,Ceglia Scott¹,Chen Jiahui³,Chen Lu³,Chen Qinghao¹,Fei Zhongbo¹,Hoerrner Scott¹,Qi Ji³^ORCID,de Lera Ruiz Manuel²,Tan Lushi¹,Wan Baoqiang³,Yin Jingjun¹

Affiliation:

1. Process Research & Development, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

2. Process Research & Development, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

3. STA Pharmaceutical R&D Co., Ltd., 90 Delin Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00569

Reference57 articles.

1. Migraine — Current Understanding and Treatment

2. Burden of Migraine in the United States

3. Emerging Target-Based Paradigms to Prevent and Treat Migraine

4. Potential mechanisms of prospective antimigraine drugs: A focus on vascular (side) effects

5. The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats

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