Asymmetric Synthesis of a 5,6,7,8-Tetrahydro-1,6-naphthyridine Scaffold Leading to Potent Retinoid-Related Orphan Receptor γt Inverse Agonist TAK-828F-Reference-Cited by-同舟云学术

Asymmetric Synthesis of a 5,6,7,8-Tetrahydro-1,6-naphthyridine Scaffold Leading to Potent Retinoid-Related Orphan Receptor γt Inverse Agonist TAK-828F

Published:2020-07-23 Issue:16 Volume:85 Page:10797-10805
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Tsuruoka Ryoji¹^ORCID,Yoshikawa Naoki¹^ORCID,Konishi Takahiro¹,Yamano Mitsuhisa¹

Affiliation:

1. Process Chemistry, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 17-85 Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c01311

Reference54 articles.

1. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2. Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

3. IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

4. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

5. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

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