Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization-Reference-Cited by-同舟云学术

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Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization

Published:2021-05-28 Issue:12 Volume:86 Page:8479-8488
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Jaime-Figueroa Saul¹,Bond Michael J.²,Vergara J. Ignacio³,Swartzel Jake C.³,Crews Craig M.¹²³^ORCID

Affiliation:

1. Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, Connecticut 06511, United States

2. Department of Pharmacology, Yale University, New Haven, Connecticut 06511, United States

3. Department of Chemistry, Yale University, New Haven, Connecticut 06511, United States

Funder

National Cancer Institute

American Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c00472

Reference34 articles.

1. Amaryllidaceae and Sceletium alkaloids

2. Isoquinoline Alkaloids and their Binding with DNA: Calorimetry and Thermal Analysis Applications

3. Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents

4. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

5. Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

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1. Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury;Angewandte Chemie International Edition;2024-02-28

2. Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury;Angewandte Chemie;2024-02-28

3. Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry;RSC Medicinal Chemistry;2023

4. Direct Access to 4-Substituted Isoquinolones via a Sequential Pd-Catalyzed Cyclization/Base-Promoted Aromatization/Ring-Opening of N-Propargyl-1,3-oxazolidines;Molecular Catalysis;2022-04

5. One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-Promoted Oxidative Ugi–Wittig Reaction Starting from Phosphonium Salt Precursors;Synlett;2021-10-04

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