Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem Transformation
Author:
Affiliation:
1. Pivotal Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b02390
Reference18 articles.
1. Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
2. Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
3. An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553
4. The Mechanism of the Disproportionation of Sulfinic Acids
5. A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines
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