Affiliation:
1. Department of Chemistry and Chemical Biology Cornell University Ithaca NY-14853 USA
Abstract
AbstractQuaternary carbons are useful motifs in chemical synthesis but can be challenging to prepare using many chemical methods. Here, we report a stereoselective synthesis of β‐quaternary lactams using flavin‐dependent ‘ene’‐reductases via a 5‐exo‐trig radical cyclization. The products are formed in moderate to good levels of enantioselectivity using an ‘ene’‐reductase variant from Zymomonas mobilis. This method highlights the opportunity for biocatalysis to form quaternary centers using non‐natural reactions.
Funder
National Science Foundation
National Institutes of Health