Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert-Reference-Cited by-同舟云学术

Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert

Published:2018-03-01 Issue:6 Volume:83 Page:3090-3108
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Curtin Brice H.¹,Manoni Francesco¹,Park Jiyong¹^ORCID,Sisto Luke J.¹,Lam Yu-hong¹,Gravel Michel²,Roulston Anne²,Harran Patrick G.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States

2. Laboratory for Therapeutic Development, Rosalind and Morris Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada

Funder

National Cancer Institute

Human Frontier Science Program

Cancer Research Coordinating Committee, University of California

D.J. and J.M. Cram Endowment

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.7b02958

Reference62 articles.

1. The exploration of macrocycles for drug discovery — an underexploited structural class

2. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

3. Targeting protein–protein interactions as an anticancer strategy

4. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

5. Peptide therapeutics: Targeting the undruggable space

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