Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir-Reference-Cited by-同舟云学术

Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir

Published:2019-02-05 Issue:8 Volume:84 Page:4932-4939
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Horváth András¹,Depré Dominique¹,A. Vermeulen Wim A.¹,Wuyts Stijn L.¹,Harutyunyan Syuzanna R.¹^ORCID,Binot Grégori¹,Cuypers Jef¹,Couck Wouter¹,Den Heuvel Dirk Van¹

Affiliation:

1. Janssen Pharmaceutica N.V., 30 Turnhoutseweg, B-2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b03124

Reference30 articles.

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2. Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

3. Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

4. Further Study of Syntheses ofdl-2,3-Dicarboxycyclopentylacetic Acids

5. Synthesis of NMHA: Raboisson, P.; De Kock, H.; Dorange, I.; Vendeville, S.; Surleraux, D.; Tahri, A.; Simonnet, Y.; Van De Vreken, W.; Hu, L.; Simmen, K.; Nilsson, K.; Samuelsson, B.; Rosenquist, A.; Wallberg, H. WO 2007014921.

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