Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin-Reference-Cited by-同舟云学术

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin

Published:2018-09-10 Issue:19 Volume:83 Page:11571-11576
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Savage Scott,McClory Andrew,Zhang Haiming^ORCID,Cravillion Theresa,Lim Ngiap-Kie,Masui Colin,Robinson Sarah J.,Han Chong^ORCID,Ochs Christoph¹,Rege Pankaj D.¹,Gosselin Francis^ORCID

Affiliation:

1. Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b01551

Reference18 articles.

1. Estrogen Receptors: Therapies Targeted to Receptor Subtypes

2. Selective estrogen receptor modulators: tissue specificity and clinical utility

3. Endocrine Therapy Resistance: Current Status, Possible Mechanisms and Overcoming Strategies

4. Hormonal Resistance in Breast Cancer: Evolving Treatment Strategies

5. Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

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