Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts-Reference-Cited by-同舟云学术

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Published:2015-05-22 Issue:12 Volume:58 Page:4888-4904
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lai Andiliy¹,Kahraman Mehmet¹,Govek Steven¹,Nagasawa Johnny¹,Bonnefous Celine¹,Julien Jackie¹,Douglas Karensa¹,Sensintaffar John¹,Lu Nhin¹,Lee Kyoung-jin¹,Aparicio Anna¹,Kaufman Josh¹,Qian Jing¹,Shao Gang¹,Prudente Rene¹,Moon Michael J.¹,Joseph James D.¹,Darimont Beatrice¹,Brigham Daniel¹,Grillot Kate¹,Heyman Richard¹,Rix Peter J.¹,Hager Jeffrey H.¹,Smith Nicholas D.¹

Affiliation:

1. Department of Chemistry, ‡Department of Biology, §Department of Drug Safety and Disposition, Seragon Pharmaceuticals, 12780 El Camino Real, Suite 302, San Diego, California 92130, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00054

Reference34 articles.

1. Estrogen Receptors: Therapies Targeted to Receptor Subtypes

2. Estrogen Receptors as Therapeutic Targets in Breast Cancer

3. Pathways to tamoxifen resistance

4. Biological determinants of endocrine resistance in breast cancer

5. Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

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