Incorporating Morpholine and Oxetane into Benzimidazolequinone Antitumor Agents: The Discovery of 1,4,6,9-Tetramethoxyphenazine from Hydrogen Peroxide and Hydroiodic Acid-Mediated Oxidative Cyclizations-Reference-Cited by-同舟云学术

Incorporating Morpholine and Oxetane into Benzimidazolequinone Antitumor Agents: The Discovery of 1,4,6,9-Tetramethoxyphenazine from Hydrogen Peroxide and Hydroiodic Acid-Mediated Oxidative Cyclizations

Published:2019-07-11 Issue:15 Volume:84 Page:9811-9818
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Conboy Darren¹^ORCID,Mirallai Styliana I.²,Craig Austin²,McArdle Patrick²,Al-Kinani Ali A.¹,Barton Stephen¹^ORCID,Aldabbagh Fawaz¹²^ORCID

Affiliation:

1. Department of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames KT1 2EE, U.K.

2. School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland

Funder

Irish Research Council

Kingston University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b01427

Reference44 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Mitigating Heterocycle Metabolism in Drug Discovery

3. Revealing quinquennial anticancer journey of morpholine: A SAR based review

4. Oxetanes in Drug Discovery: Structural and Synthetic Insights

5. Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

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