Synthesis of Functionalized Bicyclo[2.2.2]octan-2-ones Skeleton via Tandem Process of Amino Acid Involved Formal [4 + 2] and Decarboxylative–Mannich Sequence-Reference-Cited by-同舟云学术

Synthesis of Functionalized Bicyclo[2.2.2]octan-2-ones Skeleton via Tandem Process of Amino Acid Involved Formal [4 + 2] and Decarboxylative–Mannich Sequence

Published:2021-02-02 Issue:4 Volume:86 Page:3276-3286
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Mao Zhuo-Ya¹,Ye Jian-Liang²^ORCID,Nie Xiao-Di¹,Si Chang-Mei¹,Wei Bang-Guo¹^ORCID,Lin Guo-Qiang³

Affiliation:

1. School of Pharmacy and Institutes of Biomedical Sciences, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

2. College of Chemistry and Chemical Engineering and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China

3. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c02620

Reference42 articles.

1. Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

2. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

3. Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

4. Function-Oriented Synthesis, Step Economy, and Drug Design

5. Structural Simplification of Natural Products

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