1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany, Pharmaceutical Institute Poppelsdorf, University of Bonn, Kreuzbergweg 26, D-53115 Bonn, Germany, and Pharmaceutical Institute Endenich, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany