2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione Derivatives, a Class of Cytotoxic Agents Active on Multidrug-Resistant Cell Lines: Synthesis, Biological Evaluation, and Structure−Activity Relationships-Reference-Cited by-同舟云学术

2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione Derivatives, a Class of Cytotoxic Agents Active on Multidrug-Resistant Cell Lines: Synthesis, Biological Evaluation, and Structure−Activity Relationships

Published:1999-06-17 Issue:14 Volume:42 Page:2535-2541
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Antonini Ippolito¹,Polucci Paolo¹,Kelland Lloyd R.¹,Menta Ernesto¹,Pescalli Nicoletta¹,Martelli Sante¹

Affiliation:

1. Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy, Cancer Research Campaign Cancer Therapeutics Centre, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, U.K., and Boehringer Mannheim Italia, Research Center, 20052 Monza, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9805586

Reference12 articles.

1. Synthesis of (Dialkylamino)alkyl-Disubstituted Pyrimido[5,6,1-de]acridines, a Novel Group of Anticancer Agents Active on a Multidrug Resistant Cell Line

2. 6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations

3. Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias

4. 1-[(ω-Aminoalkyl)amino]-4-[N-(ω-aminoalkyl)carbamoyl]-9-oxo-9,10-dihydro- acridines as Intercalating Cytotoxic Agents: Synthesis, DNA Binding, and Biological Evaluation

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