Mutagenesis of a Specificity-Determining Residue in Tyrosine Hydroxylase Establishes That the Enzyme Is a Robust Phenylalanine Hydroxylase but a Fragile Tyrosine Hydroxylase-Reference-Cited by-同舟云学术

Mutagenesis of a Specificity-Determining Residue in Tyrosine Hydroxylase Establishes That the Enzyme Is a Robust Phenylalanine Hydroxylase but a Fragile Tyrosine Hydroxylase

Published:2013-02-13 Issue:8 Volume:52 Page:1446-1455
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Daubner S. Colette¹,Avila Audrey¹,Bailey Johnathan O.²,Barrera Dimitrios³,Bermudez Jaclyn Y.¹,Giles David H.⁴,Khan Crystal A.⁴,Shaheen Noel¹,Thompson Janie Womac²,Vasquez Jessica²,Oxley Susan P.³,Fitzpatrick Paul F.⁴

Affiliation:

1. Department of Biological Sciences, St. Mary’s University, San Antonio, Texas 78228, United States

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77840, United States

3. Department of Chemistry and Biochemistry, St. Mary’s University, San Antonio, Texas 78228, United States

4. Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi400031n

Reference60 articles.

1. Tetrahydropterin-Dependent Amino Acid Hydroxylases

2. Characterization of Chimeric Pterin-Dependent Hydroxylases: Contributions of the Regulatory Domains of Tyrosine and Phenylalanine Hydroxylase to Substrate Specificity

3. Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

4. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.

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2. The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase;Archives of Biochemistry and Biophysics;2023-02

3. Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters;Philosophical Transactions of the Royal Society B: Biological Sciences;2021-02-08

4. Mutagenesis of an Active-Site Loop in Tryptophan Hydroxylase Dramatically Slows the Formation of an Early Intermediate in Catalysis;Journal of the American Chemical Society;2018-03-28

5. Modification of the flexible loop of tyrosine hydroxylase that determines substrate specificity;The FASEB Journal;2016-04