Mutagenesis of an Active-Site Loop in Tryptophan Hydroxylase Dramatically Slows the Formation of an Early Intermediate in Catalysis-Reference-Cited by-同舟云学术

Mutagenesis of an Active-Site Loop in Tryptophan Hydroxylase Dramatically Slows the Formation of an Early Intermediate in Catalysis

Published:2018-03-28 Issue:15 Volume:140 Page:5185-5192
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Subedi Bishnu P.¹^ORCID,Fitzpatrick Paul F.¹^ORCID

Affiliation:

1. Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States

Funder

Division of Chemistry

Welch Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.8b00936

Reference41 articles.

1. Tetrahydropterin-Dependent Amino Acid Hydroxylases

2. Mechanism of Aromatic Amino Acid Hydroxylation

3. Mechanisms of tryptophan and tyrosine hydroxylase

4. A Mechanism for Hydroxylation by Tyrosine Hydroxylase Based on Partitioning of Substituted Phenylalanines

5. On the Catalytic Mechanism of Tryptophan Hydroxylase

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