1. School of Pharmacy, Martin Luther University, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle/Saale, Germany, Department DMPK&BAC, AstraZeneca R&D, S-43183 Mölndal, Germany, Department of Molecular Sciences, AstraZeneca R&D, S-43183 Mölndal, Germany, and School of Pharmacy, Johannes Gutenberg University, Staudingerweg 5, D-55099 Mainz, Germany