Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae
Author:
Affiliation:
1. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2. College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China
Funder
Ministry of Science and Technology of the People's Republic of China
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acssynbio.0c00281
Reference27 articles.
1. Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms
2. Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin
3. Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis
4. Rapid analysis of native neomycin components on a portable capillary electrophoresis system with potential gradient detection
5. Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576
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