Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis
Author:
Affiliation:
1. Department of Chemistry, ‡Department of Chemistry and Materials Science, and §Department of Bioengineering, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan
Funder
Ministry of Education, Culture, Sports, Science, and Technology
Naito Foundation
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja507759f
Reference31 articles.
1. Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms
2. Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA
3. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
4. 6'"-Deamino-6'"-hydroxy derivatives,as intermediates in the biosynthesis of neomycin and paromomycin.
5. Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin
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