Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis-Reference-Cited by-同舟云学术

Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis

Published:2017-04-26 Issue:8 Volume:6 Page:1471-1483
ISSN:2161-5063
Container-title:ACS Synthetic Biology
language:en
Short-container-title:ACS Synth. Biol.

Author:

Umenhoffer Kinga¹,Draskovits Gábor¹,Nyerges Ákos¹,Karcagi Ildikó¹,Bogos Balázs¹,Tímár Edit¹,Csörgő Bálint¹,Herczeg Róbert²,Nagy István²³,Fehér Tamás¹^ORCID,Pál Csaba¹,Pósfai György¹^ORCID

Affiliation:

1. Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, 6726 Szeged, Hungary

2. SeqOmics Biotechnology Ltd, 6782 Mórahalom, Hungary

3. Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, 6726 Szeged, Hungary

Funder

European Commission

Boehringer Ingelheim Fonds

Magyar Tudom?nyos Akad?mia

Orsz?gos Tudom?nyos Kutat?si Alapprogramok

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acssynbio.6b00378

Reference62 articles.

1. Engineering reduced evolutionary potential for synthetic biology

2. Emergent Properties of Reduced-Genome Escherichia coli

3. Reduced evolvability of Escherichia coli MDS42, an IS-less cellular chassis for molecular and synthetic biology applications

4. Low-mutation-rate, reduced-genome Escherichia coli: an improved host for faithful maintenance of engineered genetic constructs

5. When a virus is not a parasite: the beneficial effects of prophages on bacterial fitness

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