Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors-Reference-Cited by-同舟云学术

Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors

Published:2022-10-12 Issue:10 Volume:11 Page:3182-3189
ISSN:2161-5063
Container-title:ACS Synthetic Biology
language:en
Short-container-title:ACS Synth. Biol.

Author:

Scott Louis H.¹²^ORCID,Wigglesworth Mark J.³,Siewers Verena²,Davis Andrew M.⁴,David Florian²

Affiliation:

1. Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, SE-41320 Gothenburg, Sweden

2. Department of Biology and Biological Engineering, Division of Systems and Synthetic Biology, Chalmers University of Technology, SE-41296 Gothenburg, Sweden

3. Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Alderley Park SK10 2NA, U.K.

4. Discovery Sciences, Biopharmaceutical R&D, AstraZeneca, Cambridge, CB2 0AA, U.K.

Funder

AstraZeneca

VINNOVA

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acssynbio.2c00274

Reference44 articles.

1. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

2. Targeting HIF-1 for cancer therapy

3. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

4. Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A “structure-activity relationship” perspective

5. New Modalities for Challenging Targets in Drug Discovery

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