Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase
Author:
Affiliation:
1. Departments of Medicinal Chemistry and Biochemistry, IRBM-MRL Rome, Via Pontina, Km 30.600, 00040 Pomezia, Rome, Italy
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm0342109
Reference19 articles.
1. An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
2. Emerging therapies for hepatitis C virus infection
3. Hepatitis C Virus Infection
4. Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
5. A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
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