Single-Site Mutational Engineering and Following MonoPEGylation of the Human Lectin Galectin-2: Effects on Ligand Binding, Functional Aspects, and Clearance from Serum-Reference-Cited by-同舟云学术

Single-Site Mutational Engineering and Following MonoPEGylation of the Human Lectin Galectin-2: Effects on Ligand Binding, Functional Aspects, and Clearance from Serum

Published:2013-04-24 Issue:5 Volume:10 Page:2054-2061
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Kopitz Jürgen¹,Fik Zdenek²³,André Sabine⁴,Smetana Karel²,Gabius Hans-Joachim⁴

Affiliation:

1. Abteilung Angewandte Tumorbiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany

2. Institute of Anatomy, First Faculty of Medicine, Charles University, U Nemocnice 3, 128 00 Prague 2, Czech Republic

3. Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University, V Úvalu 5, 150 00 Prague 5, Czech Republic

4. Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinärstr. 13, 80539 München, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp4000629

Reference49 articles.

1. Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition

2. From lectin structure to functional glycomics: principles of the sugar code

3. Pegylation

4. Polyethylene glycol–superoxide dismutase, a conjugate in search of exploitation

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