Force Field Design and Molecular Dynamics Simulations of the Carbapenem- and Cephamycin-Resistant Dinuclear Zinc Metallo-β-lactamase from Bacteroides fragilis and Its Complex with a Biphenyl Tetrazole Inhibitor-Reference-Cited by-同舟云学术

Force Field Design and Molecular Dynamics Simulations of the Carbapenem- and Cephamycin-Resistant Dinuclear Zinc Metallo-β-lactamase from Bacteroides fragilis and Its Complex with a Biphenyl Tetrazole Inhibitor

Published:2005-02-10 Issue:5 Volume:48 Page:1630-1637
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Park Hwangseo¹,Merz Kenneth M.¹

Affiliation:

1. 104 Chemistry Building, Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802-6300

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0491290

Reference53 articles.

1. The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.

2. Crystal Structure of the Zinc-Dependent β-Lactamase from Bacillus cereus at 1.9 Å Resolution: Binuclear Active Site with Features of a Mononuclear Enzyme,

3. Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor,

4. Succinic Acids as Potent Inhibitors of Plasmid-borne IMP-1 Metallo-β-lactamase

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