The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent-Reference-Cited by-同舟云学术

The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent

Published:2002-07-13 Issue:17 Volume:45 Page:3692-3702
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavetsias V.¹,Skelton L. A.¹,Yafai F.¹,Mitchell F.¹,Wilson S. C.¹,Allan B.¹,Jackman A. L.¹

Affiliation:

1. Cancer Research U.K. Centre for Cancer Therapeutics at The Institute of Cancer Research, Chemistry Department, Cancer Research U.K. Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm011081s

Reference15 articles.

1. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action

2. A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

3. Synthesis and biological properties of 3-methyl-10-propargyl-5,8-dideazafolic acid

4. Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent

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