Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent-Reference-Cited by-同舟云学术

Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent

Published:1996-01-01 Issue:3 Volume:39 Page:695-704
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hennequin Laurent F.¹,Boyle F. Thomas¹,Wardleworth J. Michael¹,Marsham Peter R.¹,Kimbell Rosemary¹,Jackman Ann L.¹

Affiliation:

1. Zeneca Pharma, Centre de recherches, Z. I. La Pompelle, BP 401, 51064 Reims, France, Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, England, and CRC Centre for Cancer Therapeutics at the Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm950645n

Reference33 articles.

1. A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717.

2. Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor, CB3717

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