1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
Author:
Affiliation:
1. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany
2. DMPK, GlaxoSmithKline, Park Road, Ware SG12 0DP, U.K.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml5002932
Reference24 articles.
1. Suppression of inflammation by a synthetic histone mimic
2. Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains
3. Selective inhibition of BET bromodomains
4. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
5. Discovery of BET bromodomain inhibitors and their role in target validation
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