Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase-Reference-Cited by-同舟云学术

Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase

Published:2008-08-12 Issue:35 Volume:130 Page:11598-11599
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Castonguay Roselyne¹,Valenzano Chiara R.¹,Chen Alice Y.¹,Keatinge-Clay Adrian¹,Khosla Chaitan¹,Cane David E.¹

Affiliation:

1. Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, the Departments of Chemical Engineering, Chemistry, and Biochemistry, Stanford University, Stanford, California 94305, and the Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158-2517

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja804453p

Reference23 articles.

1. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae

2. Cf.the closely related PKS clusters for niddamycin synthase, UniProt ID O30764 and platenolide (spiramycin) synthase:

3. Production of a novel polyketide through the construction of a hybrid polyketide synthase

4. Also:Burgett, S. G., Kuhstoss, S. A., Rao, R. N., Richardson, M. A., and Rosteck, P. R., Jr.Platenolide synthase gene. U.S. Patent 5,945,320, 1999.

5. Structure and Mechanism of the 6-Deoxyerythronolide B Synthase

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