Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic-Reference-Cited by-同舟云学术

Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic

Published:2008-08-01 Issue:16 Volume:51 Page:5109-5117
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Balboni Gianfranco¹,Fiorini Stella¹,Baldisserotto Anna¹,Trapella Claudio¹,Sasaki Yusuke¹,Ambo Akihiro¹,Marczak Ewa D.¹,Lazarus Lawrence H.¹,Salvadori Severo¹

Affiliation:

1. Department of Toxicology, University of Cagliari, I-09124 Cagliari, Italy, Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, I-44100 Ferrara, Italy, Department of Pharmacology, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-Ku, Sendai 981-8558, Japan, Medicinal Chemistry Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800587e

Reference49 articles.

1. δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

2. Selective Opioid Dipeptides

3. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

4. Evolution of the Dmt-Tic Pharmacophore: N-Terminal Methylated Derivatives with Extraordinary δ Opioid Antagonist Activity

5. Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties

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