Quantitative Analysis of the Leaky Expression of Adenovirus Genes in Cells Transduced with a Replication-Incompetent Adenovirus Vector-Reference-Cited by-同舟云学术

Quantitative Analysis of the Leaky Expression of Adenovirus Genes in Cells Transduced with a Replication-Incompetent Adenovirus Vector

Published:2011-06-17 Issue:4 Volume:8 Page:1430-1435
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Shimizu Kahori¹,Sakurai Fuminori¹,Machitani Mitsuhiro¹,Katayama Kazufumi¹,Mizuguchi Hiroyuki¹²³

Affiliation:

1. Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan

2. Laboratory of Stem Cell Regulation, National Institute of Biomedical Innovation, 7-6-8 Asagi Saito, Ibaraki, Osaka, 567-0085, Japan

3. The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp200121z

Reference28 articles.

1. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

2. MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

3. Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.

4. Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy

5. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

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