Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication-Reference-Cited by-同舟云学术

Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ehrenfeld Maximilian¹,Segeth Felicia²³,Mantwill Klaus¹,Brockhaus Corinna¹,Zhao Yuling¹,Ploner Christian⁴,Kolk Andreas²,Gschwend Jürgen E.¹,Nawroth Roman¹,Holm Per Sonne¹²⁵^ORCID

Affiliation:

1. Department of Urology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

2. Department of Oral and Maxillofacial Surgery, Medical University of Innsbruck, Innsbruck, Austria

3. Department of Molecular Biology, Leopold-Franzens-Universität Innsbruck, Austria

4. Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria

5. XVir Therapeutics GmbH, Munich, Germany

Abstract

E1-deleted AdV vectors are considered replication deficient and are important tools for the study of virus biology, gene therapy, and large-scale vaccine development. However, deletion of the E1 genes does not completely abolish viral DNA replication in cancer cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00370-23

Reference55 articles.

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5. Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication

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