Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents-Reference-Cited by-同舟云学术

Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

Published:2010-09-01 Issue:19 Volume:53 Page:6825-6837
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Krečmerová Marcela¹,Holý Antonín¹,Andrei Graciela²,Pomeisl Karel¹,Tichý Tomáš¹,Břehová Petra¹,Masojídková Milena¹,Dračínský Martin¹,Pohl Radek¹,Laflamme Genevieve³,Naesens Lieve²,Hui Hon³,Cihlar Tomas³,Neyts Johan²,De Clercq Erik²,Balzarini Jan²,Snoeck Robert²

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Gilead Sciences and IOCB Research Centre, Flemingovo nám. 2, CZ-166 10, Prague 6, Czech Republic

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

3. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901828c

Reference47 articles.

1. Vaccinia Virus Replication I. Requirement for the Host-Cell Nucleus

2. Perspective: Discovery of antivirals against smallpox

3. Severe Eczema Vaccinatum in a Household Contact of a Smallpox Vaccinee

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