Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors-Reference-Cited by-同舟云学术

Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors

Published:2023-03-09 Issue:4 Volume:43 Page:1019-1037
ISSN:0198-6325
Container-title:Medicinal Research Reviews
language:en
Short-container-title:Medicinal Research Reviews

Author:

Tang Hairong¹²,Zhang Ao¹²³^ORCID

Affiliation:

1. Shanghai Frontiers Science Center for Drug Target Identification and Delivery, and the Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, School of Pharmaceutical Sciences Shanghai Jiao Tong University Shanghai China

2. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy Shanghai Jiao Tong University Shanghai China

3. Lingang Laboratory Shanghai China

Abstract

AbstractAlthough monkeypox (mpox) has been endemic in Western and Central Africa for 50 years, it has not received sufficient prophylactic and therapeutical attention to avoid evolving into an epidemic. From January 2022 to January 2023, more than 84,000 of mpox cases were reported from 110 countries worldwide. Case numbers appear to be rising every day, making mpox an increasing global public health threat for the foreseeable future. In this perspective, we review the known biology and epidemiology of mpox virus, together with the latest therapeutic options available for mpox treatment. Further, small molecule inhibitors against mpox virus and the future directions in this field are discussed as well.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/med.21943

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