Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction-Reference-Cited by-同舟云学术

Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction

Published:2009-10-26 Issue:22 Volume:52 Page:7044-7053
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Allen John G.¹,Bourbeau Matthew P.¹,Wohlhieter G. Erich¹,Bartberger Michael D.¹,Michelsen Klaus¹,Hungate Randall¹,Gadwood Robert C.²,Gaston Rick D.²,Evans Bruce²,Mann Larry W.²,Matison Michael E.²,Schneider Stephen³,Huang Xin³,Yu Dongyin⁴,Andrews Paul S.³,Reichelt Andreas¹,Long Alexander M.³,Yakowec Peter³,Yang Evelyn Y.⁵,Lee Tani Ann⁴,Oliner Jonathan D.⁴

Affiliation:

1. Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320

2. Kalexsyn Inc. 4502 Campus Drive, Kalamazoo, Michigan 49008

3. Chemistry Research and Discovery, Amgen, Inc., One Kendall Square, Cambridge Massachusetts 02139

4. Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320

5. Protein Science, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900681h

Reference52 articles.

1. Control of apoptosis by p53

2. The genetics of the p53 pathway, apoptosis and cancer therapy

3. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

4. Crippling p53 activities via knock-in mutations in mouse models

5. What have animal models taught us about the p53 pathway?

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