Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale-Reference-Cited by-同舟云学术

Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale

Published:2011-08-12 Issue:5 Volume:15 Page:1185-1191
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wang Xiao-Jun¹,Frutos Rogelio P.¹,Zhang Li¹,Sun Xiufeng¹,Xu Yibo¹,Wirth Thomas²,Nicola Thomas²,Nummy Lawrence J.¹,Krishnamurthy Dhileep¹,Busacca Carl A.¹,Yee Nathan¹,Senanayake Chris H.¹

Affiliation:

1. Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, United States

2. Department of Production and Engineering, Boehringer Ingelheim GmbH & Co.KG, 55216 Ingelheim am Rhein, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200175t

Reference25 articles.

1. Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors: 1H-Imidazo[1,2-α]imidazol-2-one Derivatives

2. Binding Site Elucidation of Hydantoin-Based Antagonists of LFA-1 Using Multidisciplinary Technologies: Evidence for the Allosteric Inhibition of a Protein−Protein Interaction

3. Self-Regeneration of Stereocenters(SRS)—Applications, Limitations, and Abandonment of a Synthetic Principle

4. Self-Regeneration of Stereocenters: A Practical Enantiospecific Synthesis of LFA-1 Antagonist BIRT-377

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