Computational Approaches Elucidate the Allosteric Mechanism of Human Aromatase Inhibition: A Novel Possible Route to Small-Molecule Regulation of CYP450s Activities?-Reference-Cited by-同舟云学术

Computational Approaches Elucidate the Allosteric Mechanism of Human Aromatase Inhibition: A Novel Possible Route to Small-Molecule Regulation of CYP450s Activities?

Published:2014-09-15 Issue:10 Volume:54 Page:2856-2868
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Sgrignani Jacopo¹,Bon Marta²,Colombo Giorgio¹,Magistrato Alessandra²

Affiliation:

1. Istituto di Chimica del Riconoscimento Molecolare, CNR, Via Mario Bianco 9, 20131 Milano, Milano, Italy

2. CNR-IOM-Democritos National Simulation Center c/o SISSA, via Bonomea 265, 34165 Trieste, Trieste, Italy

Funder

Regione Lombardia

Associazione Italiana Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci500425y

Reference82 articles.

1. Human aromatase: Perspectives in biochemistry and biotechnology

2. Aromatase: The Enzyme and Its Inhibition

3. A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17)

4. Estrogen and Cancer

5. Challenges, controversies, breakthroughs

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances of Predicting Allosteric Mechanisms Through Protein Contact in New Technologies and Their Application;Molecular Biotechnology;2023-11-13

2. The “outsized” role of the I‐helix kink in human Cytochrome P450s;Clinical and Translational Medicine;2023-09

3. Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis;Steroids;2023-08

4. Synthesis of new 1,2,3-triazole-based compounds of potential anti-breast cancer activity targeting aromatase enzyme inhibition;Egyptian Journal of Chemistry;2023-02-01

5. Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy;European Journal of Medicinal Chemistry;2022-12