Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts

Author:

Cruz Patricia G.1,Fribley Andrew M.2,Miller Justin R.2,Larsen Martha J.1,Schultz Pamela J.1,Jacob Renju T.1,Tamayo-Castillo Giselle3,Kaufman Randal J.4,Sherman David H.1

Affiliation:

1. Center for Chemical Genomics, Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109-2216, United States

2. Carmen and Ann Adams Department of Pediatrics, Division of Hematology and Oncology, and the Karmanos Cancer Institute Molecular Therapeutics Program, Wayne State University, 2228 Elliman Building, 421 East Canfield, Detroit, Michigan 48201, United States

3. Instituto Nacional de Biodiversidad (INBio), Heredia, Costa Rica & CIPRONA-Escuela de Química, Universidad de Costa Rica (UCR), 2061-San José, Costa Rica

4. Degenerative Disease Research Program, Center for Cancer Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States

Funder

National Science Foundation

Hyundai Motor America

Children's research foundation of Michigan

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

National Institute of Dental and Craniofacial Research

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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