Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI-Reference-Cited by-同舟云学术

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

Published:2016-01-13 Issue:3 Volume:7 Page:312-317
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Pero Joseph E.¹,Rossi Michael A.¹,Kelly Michael J.¹,Lehman Hannah D. G. F.¹,Layton Mark E.¹,Garbaccio Robert M.¹,O’Brien Julie A.¹,Magliaro Brian C.¹,Uslaner Jason M.¹,Huszar Sarah L.¹,Fillgrove Kerry L.¹,Tang Cuyue¹,Kuo Yuhsin¹,Joyce Leo A.¹,Sherer Edward C.¹,Jacobson Marlene A.¹

Affiliation:

1. Departments of †Medicinal Chemistry, ‡In Vitro Sciences, §Psychiatry Research, ∥Central Pharmacology, ⊥Drug Metabolism, #Process and Analytical Chemistry, and ∇Structural Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00459

Reference33 articles.

1. The de Facto US Mental and Addictive Disorders Service System

2. Schizophrenia, “Just the Facts”: What we know in 2008

3. Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology

4. Pharmacological treatment of primary negative symptoms in schizophrenia: A systematic review

5. Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

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