Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor-Reference-Cited by-同舟云学术

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor

Published:2016-03-09 Issue:5 Volume:7 Page:476-481
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hatcher John M.¹²,Weisberg Ellen³,Sim Taebo⁴⁵,Stone Richard M.³,Liu Suiyang³,Griffin James D.³,Gray Nathanael S.¹²

Affiliation:

1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States

2. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Avenue, Longwood Center LC-2209, Boston, Massachusetts 02115, United States

3. Department of Medical Oncology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

4. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea

5. Graduate School of Converging Science and Technology, KU-KIST, 145, Anam-ro, Seongbuk-gu, Seoul 136-713, Korea

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00498

Reference29 articles.

1. The role of FLT3 in haematopoietic malignancies

2. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

3. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Palladium-catalyzed tandem carbonylative synthesis of indeno[1,2-b]indol-10(5H)-one scaffolds from 2-alkynylanilines;Journal of Catalysis;2023-12

2. CuBr2@g-C3N4-catalyzed cyclization of aromatic alkyne ketones to obtain indenones with K2S2O8 under blue light irradiation;Tetrahedron Letters;2023-06

3. A Tandem Nucleophilic Aminopalladation and Carbene Insertion Sequence for Indole Fused Polycycles;Organic Letters;2021-09-07

4. Recent advances in FLT3 inhibitors for acute myeloid leukemia;Future Medicinal Chemistry;2020-05

5. Rational Drug Design Approach of Receptor Tyrosine Kinase Type III Inhibitors;Current Medicinal Chemistry;2020-01-08